Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 19 0.0 0.701 0.228 0.236
biological_process el 19 0.078 0.96 0.616 0.298
biological_process ka 19 0.0 0.682 0.218 0.247
biological_process rf 19 0.0 0.701 0.228 0.236
cellular_component ct 1 0.002 0.002 0.002 0.0
cellular_component el 1 0.218 0.218 0.218 0.0
cellular_component ka 1 0.004 0.004 0.004 0.0
cellular_component rf 1 0.001 0.001 0.001 0.0
disease ct 11 0.002 0.649 0.067 0.184
disease el 11 0.04 0.823 0.645 0.216
disease ka 11 0.001 0.701 0.07 0.2
disease rf 11 0.002 0.654 0.067 0.186
genetic_interaction ct 16 0.025 0.95 0.524 0.287
genetic_interaction el 16 0.027 1.0 0.549 0.265
genetic_interaction ka 16 1.0 1.0 1.0 0.0
genetic_interaction rf 16 0.025 1.0 0.554 0.297
molecular_function ct 16 0.0 0.936 0.471 0.303
molecular_function el 16 0.013 0.907 0.609 0.25
molecular_function ka 16 0.0 0.925 0.471 0.308
molecular_function rf 16 0.0 0.936 0.471 0.303
pathway ct 4 0.06 0.226 0.147 0.062
pathway el 4 0.003 0.169 0.098 0.064
pathway ka 4 0.003 1.0 0.537 0.466
pathway rf 4 0.042 0.176 0.104 0.05
phenotype ct 11 0.001 0.267 0.06 0.095
phenotype el 11 0.278 0.971 0.694 0.204
phenotype ka 11 0.001 0.412 0.085 0.129
phenotype rf 11 0.001 0.267 0.06 0.095
protein_interaction ct 20 0.0 0.668 0.076 0.162
protein_interaction el 20 0.0 0.715 0.073 0.171
protein_interaction ka 20 0.002 1.0 0.701 0.457
protein_interaction rf 20 0.0 0.659 0.074 0.159

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 20 0.0 0.704 0.326 0.235
integration_mean_by_presence el 20 0.001 0.762 0.128 0.186
integration_mean_by_presence ka 20 0.0 0.842 0.157 0.226
integration_mean_by_presence rf 20 0.001 0.353 0.064 0.098
mean ct 20 0.0 0.704 0.324 0.252
mean el 20 0.0 0.795 0.131 0.192
mean ka 20 0.0 0.846 0.141 0.224
mean rf 20 0.0 0.366 0.085 0.119

CDF plots of non integrated kernels

CDF plots of integrated kernels